DR.HongCai Wang

Dr. Wang is an expert in pharmacology and toxicology of Chinese material medica. Dr. Wang received a Ph.D. from Shanghai International Acupuncture Training Academy, and a Master’s degree from Tongji Medical University.

ACADEMIC EDUCATION

MD, Tongji Medical University, China

Ph D, Shanghai International Acupuncture Training Academy

MAIN POSITIONS

1985─1990  Assistant, CACMS

1991-1994          Assistant professor, CACMS

1993─1994  Pluralistic personnel, National Natural Science Foundation Committee

1995-1999   Associate professor, CACMS

1996- 1997   Visiting scholar, Tokyo University of Pharmacy & Life Science, Japan

1999—present  Professor,CACMS

2005—present  Head of Center of Safety Evaluation for Chinese Materia Medica, ICMM, CACMS

RESEARCH FIELD:   Pharmacology and toxicology of Chinese material medica

PARTICIPATION IN BOARDS AND COMMITTEES

Member of the expert board for health-care food appraisal in State Food and Drug Administration

Advisor for OTC consultation in State Food and Drug Administration

Member of expert group for Evaluating Medical Accident in Chinese Society of Medicine

Member in the Board of Directors of Association of Medicine of DongChen district, Beijing.

Commissioner in the Board of Directors of Hazard Evaluation, Chinese Society of Environmental Mutagen

Peer reviewing expert of National Natural Science Foundation Committee

Member of expert board for evaluating of the program and academic award of Beijing Science and Technology Committee

Member of expert group for Academic Program and Academic Award Evaluation in Department of Science and Technology of Shandong Province

Member of expert board for Academic Program and Academic Award Evaluation in Department of Science and Technology of Jiangsu Province

Member of expert group for Academic Program and Academic Award Evaluation in Department of Science and Technology of Beijing

Member of expert group for Appraisal of International Cooperation Program in Ministry of Science and Technology of China

Main Grants

a)       National Natural Science Foundation, Inhibition of antibiotic-induced lipopolysaccharide (LPS) release from bacterial by a polypeptide, Principal Investigator

b)       National Natural Science Foundation, Neutralizing activity of natural products against the toxicity of bacterial endotoxin, Principal Investigator

c)       International Cooperative Project in Ministry of Science and Technology of China, Herbal-western drug interaction, Principal Investigator

d)       State Key Project, Hypersusceptibility of Injection of Chinese herbal medicine, Principal Investigator

e)       National Natural Science Foundation, Substances and the mechanism for embryo toxicity of Senecio, Principal Investigator

f)        Basic Research Project in Ministry of Science and Technology of China, Toxicological study and safety evaluation of Cinnabar and Realgar, Principal Investigator

g)       Beijing Natural Science Foundation, Effect on aristolochic acid-induced nephrotoxicity by P-450 mediated drug-drug interaction, Principal Investigator

h)       Beijing Natural Science Foundation, Study on enzymatic mechanism of individual difference of aristolochic acid-induced toxicity, Principal Investigator

i)        Beijing municipal project, Development of animal models of drug-resistance of cancer, Principal Investigator

j)        The Science and Technology Development Fund of Macau, Anti-influenza effect of a Chinese formula, Principal Investigator

k)       State Administration of Traditional Chinese Medicine of China, Nephrotoxicity and mechanism of Chinese herbs containing aristolochic acids

AWARDS

2000   Awarded a title of “The Outstanding Youth” by State Administration of Traditional Chinese Medicine of China

2000   Awarded a title of “The Outstanding Youth” by State Organs Work Committee of China

2001   Awarded the Academic Prize of Beijing Science and Technology Advancement

2005   Awarded the prize of Academic of Science and Technology Advancement Prize by CACMS

PUBLICATIONS (Language: Chinese)

  1. Xie Zong-wan and Wang Hongcai, eds.  New Theoretical Study on the Biological Origins of Chinese Medicinal Herbs.  The People’s Health Publishing House, 1995
  2. Zhang Boli, Weng Weiliang, Wang Hongcai, et al. eds. Adverse Effect and Rational Application of Chinese Medicine, The Publishing House of Qinghua University, 2007

PAPERS

Published in international journals:

  1. Hongcai, W., Ohno N., and Yadomae T. Inhibition of Antibiotic-induced Lysis and Lipopolysaccharide Release from Escherichia coli O111:B4 by Egg White Lysozyme.  Journal of Endotoxin Research, 1997, 4(2):105-114.
  2. Ohno N., Takada K., Kurasawa T., Hongcai, W., and Yadomae T. Detoxification of Lipopolysaccharide by Lysozyme, Prog. Clin. Biol. Res.1998,397:179-190
  3. Hongcai, W., Ohno N., and Yadomae T., Egg White Lysozyme Inhibits Ceftazidime-Induced Endotoxin Release and Filamentation of Escherichia Coli O111:B4.  Drug Dev. Res. 1998, 44:70-79
  4. Hongcai, W., Sugawara N., Ohno N., Adachi Y., and Yadomae T., Effect of O-Antigenic Polysaccharide of Escherichia coli on Endotoxin Neutralizing Activity of Lysozyme.  FEMS Immunol. Med. Microb. 1998, 21:79-87
  5. Pharmacokinetic Studies of Artemisinin(Qinghaosu) and its Derivatives by High Performace Liquid Chromatographic Methods, The Meeting of the SWG-CHEMAL of WHO, 24-26 April, 1989, Beijing, China
  6. Effect of Korea Red Ginseng on Substance Metabolism and Endocrinic Function in Animals, Korea J. Ginseng Sci. 1990,14(2):210-212

Published in domestic journals:

  1. Zhao Jing, Hongcai, W., Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica, Chinese Journal of Experimental Traditional Medical Formulae, 2009, 15(5):79-83
  2. Liu Ting, Hongcai, Wang, Yi Yan, Li Chunying, Zhao Yong, Hao Ran, Cao Chunyu, Comparative study on allergen assessment animal models in brown norway rat and guinea pig, China Journal of Chinese Materia Medica,2009,34(04):472-475
  3. Hongcai, Wang, Advance on safety evaluation of carrageenan, China Journal of Chinese Materia Medica,2009,34(05):512-514
  4. Hongcai, Wang, Wang Jinhua, Xue Baoyun, Li Chunying, Liu Ting, Zhao Yong, Cao Chunyu, Yi Yan, Study on hepatoxicity and nephrotoxicity of cinnabar in rats, China Journal of Chinese Materia Medica,2009,34(03):312-318
  5. Li Chun-Ying, Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Zhao Yong, Liu Ting, Cao Chun-Yu, Cui Xiao-Lan, Gao Yin-Jie, A Pharmacodynamic Study on Extract from Andrographis paniculata Nees, Chinese Journal of Experimental Traditional Medical Formulae, 2009, 15(10):94-99
  6. Shen Guolin, Hongcai, Wang, Zhao Yong, Cao Chunyu, Liu Ting, Li Chunying, Odd Georg Nilsen, Interaction between four herb compounds and a western drug by CYP3A4 enzyme metabolism in vitro, China Journal of Chinese Materia Medica,2009,34(13):1705-1711
  7. Cao Chunyu, Hongcai, Wang, Zhao Yong, Liu Ting, Li Chunying, Yi Yan, Wang Jinhua, Xue Baoyun, Timothy M Chan, Odd G Nilsen. Anti-thrombosis effect and its mechanism of Qingkailing injection. China Journal of Chinese Materia Medica,2009,34(12):1549-1552
  8. Hongcai, Wang, Li Chunying, Liu Ting, Zhao Yong, Cao Chunyu, Xun Baoyun, Wang Jinhua, Study on embryo toxicity of Cinnabaris, China Journal of Chinese Materia Medica,2009,34(21):2794-2798
  9. Hongcai, Wang. Zebrafish-A Useful Model For Pharmacodynamics And Toxicity Screening Of Traditional Chinese Medicine. China Journal of Chinese Materia Medica,2009,34(22):2839-2842
  10. Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying . Development of virulent heat-evil-induced thrombosis animal model. China Journal of Chinese Materia Medica,2008,33(18):2124-2128
  11. Tang Xi-Lan, Hongcai, Wang, Yu Chang-An, Liu Ting, Zhao Yong, Cao Chun-Yu, Li Chun-Ying, Yi Yan, Hao Ran. Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity. China Journal of Chinese Materia Medica,2008,33(17):2164-2169
  12. Wang Xiukun, Zhao Yong, Hongcai, Wang, Liu Ting, Li Chunying, Tang Xilan, Yi Yan, Tang Hongjun, Ye Zuguang. Experimental study on acute toxicity of climbing groundsel herb from different producing areas.  ADRJ, April, 2008,10(2):81-85
  13. Yi Yan, Hongcai, Wang, Liu Ting, Zhao Yong, Cao Chun-Yu. Analysis of causes for adverse reaction of Yuxingcao injection. China Journal of Chinese Materia Medica,2008,33(21):2439-2439
  14. Hongcai, W., Timothy M Chan, Analysis and discussion of clinical relativity between virulent heat evils and thrombosis -related diseases, China Journal of Chinese Materia Medica, 2008,33(4):476-481
  15. Hongcai, W, et al, Inflammatory mechanism for thrombosis and blood stasis animal model induced by endotoxin in combination with carrageenan, China Journal of Chinese Materia Medica, 2007, 32(1):45-48
  16. Dong Wei, Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying, Wang Xiu-Kun. Cholagogic Effect and Hepatoprotective Effect of Longdan Xiegan Pill (with Caulis Akebial Australis) on Experimental Cholestasis in Mice. China Journal of Chinese Materia Medica,Chinese Journal of Experimental Traditional Medical Formulae, 2007, 13(10):37-40
  17. Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying. Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion. Chinese Journal of Experimental Traditional Medical Formulae, 2007, 13(2)::55-57
  18. Gao Xiao-Xin, Hongcai, Wang, Zhang Su-Qin. Review of Chinese Herbal Medicine of Influencing on Cytochrome p450 System. Chinese Journal of Experimental Traditional Medical Formulae,Chinese Journal of Experimental Traditional Medical Formulae, 2006, 12(9)::64-67
  19. Hongcai, Wang. Status and Problem of Injection Made from Chinese Medicine. China Journal of Chinese Materia Medica,2007,32(11):1118-1120

Hongcai, Wang,~, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying. Inhibition of Qingkailing Injection on Endotoxin-induced Inflammatory Factor Production in Rats. China Journal of Chinese Materia Medica,2007,32(12):1240-1241

Inspired by tradition, pursuit with technology