Dr. Wang is an expert in pharmacology and toxicology of Chinese material medica. Dr. Wang received a Ph.D. from Shanghai International Acupuncture Training Academy, and a Master’s degree from Tongji Medical University.
ACADEMIC EDUCATION
MD, Tongji Medical University, China
Ph D, Shanghai International Acupuncture Training Academy
MAIN POSITIONS
1985─1990 Assistant, CACMS
1991-1994 Assistant professor, CACMS
1993─1994 Pluralistic personnel, National Natural Science Foundation Committee
1995-1999 Associate professor, CACMS
1996- 1997 Visiting scholar, Tokyo University of Pharmacy & Life Science, Japan
1999—present Professor，CACMS
2005—present Head of Center of Safety Evaluation for Chinese Materia Medica, ICMM， CACMS
RESEARCH FIELD: Pharmacology and toxicology of Chinese material medica
PARTICIPATION IN BOARDS AND COMMITTEES
Member of the expert board for health-care food appraisal in State Food and Drug Administration
Advisor for OTC consultation in State Food and Drug Administration
Member of expert group for Evaluating Medical Accident in Chinese Society of Medicine
Member in the Board of Directors of Association of Medicine of DongChen district, Beijing.
Commissioner in the Board of Directors of Hazard Evaluation, Chinese Society of Environmental Mutagen
Peer reviewing expert of National Natural Science Foundation Committee
Member of expert board for evaluating of the program and academic award of Beijing Science and Technology Committee
Member of expert group for Academic Program and Academic Award Evaluation in Department of Science and Technology of Shandong Province
Member of expert board for Academic Program and Academic Award Evaluation in Department of Science and Technology of Jiangsu Province
Member of expert group for Academic Program and Academic Award Evaluation in Department of Science and Technology of Beijing
Member of expert group for Appraisal of International Cooperation Program in Ministry of Science and Technology of China
Main Grants
a) National Natural Science Foundation, Inhibition of antibiotic-induced lipopolysaccharide (LPS) release from bacterial by a polypeptide, Principal Investigator
b) National Natural Science Foundation, Neutralizing activity of natural products against the toxicity of bacterial endotoxin, Principal Investigator
c) International Cooperative Project in Ministry of Science and Technology of China, Herbal-western drug interaction, Principal Investigator
d) State Key Project, Hypersusceptibility of Injection of Chinese herbal medicine, Principal Investigator
e) National Natural Science Foundation, Substances and the mechanism for embryo toxicity of Senecio, Principal Investigator
f) Basic Research Project in Ministry of Science and Technology of China, Toxicological study and safety evaluation of Cinnabar and Realgar, Principal Investigator
g) Beijing Natural Science Foundation, Effect on aristolochic acid-induced nephrotoxicity by P-450 mediated drug-drug interaction, Principal Investigator
h) Beijing Natural Science Foundation, Study on enzymatic mechanism of individual difference of aristolochic acid-induced toxicity, Principal Investigator
i) Beijing municipal project, Development of animal models of drug-resistance of cancer, Principal Investigator
j) The Science and Technology Development Fund of Macau, Anti-influenza effect of a Chinese formula, Principal Investigator
k) State Administration of Traditional Chinese Medicine of China, Nephrotoxicity and mechanism of Chinese herbs containing aristolochic acids
AWARDS
2000 Awarded a title of “The Outstanding Youth” by State Administration of Traditional Chinese Medicine of China
2000 Awarded a title of “The Outstanding Youth” by State Organs Work Committee of China
2001 Awarded the Academic Prize of Beijing Science and Technology Advancement
2005 Awarded the prize of Academic of Science and Technology Advancement Prize by CACMS
PUBLICATIONS (Language: Chinese)
- Xie Zong-wan and Wang Hongcai, eds. New Theoretical Study on the Biological Origins of Chinese Medicinal Herbs. The People’s Health Publishing House, 1995
- Zhang Boli, Weng Weiliang, Wang Hongcai, et al. eds. Adverse Effect and Rational Application of Chinese Medicine, The Publishing House of Qinghua University, 2007
PAPERS
Published in international journals:
- Hongcai, W., Ohno N., and Yadomae T. Inhibition of Antibiotic-induced Lysis and Lipopolysaccharide Release from Escherichia coli O111:B4 by Egg White Lysozyme. Journal of Endotoxin Research, 1997, 4(2):105-114.
- Ohno N., Takada K., Kurasawa T., Hongcai, W., and Yadomae T. Detoxification of Lipopolysaccharide by Lysozyme, Prog. Clin. Biol. Res.1998,397:179-190
- Hongcai, W., Ohno N., and Yadomae T., Egg White Lysozyme Inhibits Ceftazidime-Induced Endotoxin Release and Filamentation of Escherichia Coli O111:B4. Drug Dev. Res. 1998, 44:70-79
- Hongcai, W., Sugawara N., Ohno N., Adachi Y., and Yadomae T., Effect of O-Antigenic Polysaccharide of Escherichia coli on Endotoxin Neutralizing Activity of Lysozyme. FEMS Immunol. Med. Microb. 1998, 21:79-87
- Pharmacokinetic Studies of Artemisinin(Qinghaosu) and its Derivatives by High Performace Liquid Chromatographic Methods, The Meeting of the SWG-CHEMAL of WHO, 24-26 April, 1989, Beijing, China
- Effect of Korea Red Ginseng on Substance Metabolism and Endocrinic Function in Animals, Korea J. Ginseng Sci. 1990，14(2):210-212
Published in domestic journals:
- Zhao Jing, Hongcai, W., Caco-2 Cell Model and Its Application in the Absorption and Transportation Research of Chinese Materia Medica, Chinese Journal of Experimental Traditional Medical Formulae, 2009, 15(5):79-83
- Liu Ting, Hongcai, Wang, Yi Yan, Li Chunying, Zhao Yong, Hao Ran, Cao Chunyu, Comparative study on allergen assessment animal models in brown norway rat and guinea pig, China Journal of Chinese Materia Medica,2009,34(04):472-475
- Hongcai, Wang, Advance on safety evaluation of carrageenan, China Journal of Chinese Materia Medica,2009,34(05):512-514
- Hongcai, Wang, Wang Jinhua, Xue Baoyun, Li Chunying, Liu Ting, Zhao Yong, Cao Chunyu, Yi Yan, Study on hepatoxicity and nephrotoxicity of cinnabar in rats, China Journal of Chinese Materia Medica,2009,34(03):312-318
- Li Chun-Ying, Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Zhao Yong, Liu Ting, Cao Chun-Yu, Cui Xiao-Lan, Gao Yin-Jie, A Pharmacodynamic Study on Extract from Andrographis paniculata Nees, Chinese Journal of Experimental Traditional Medical Formulae, 2009, 15(10):94-99
- Shen Guolin, Hongcai, Wang, Zhao Yong, Cao Chunyu, Liu Ting, Li Chunying, Odd Georg Nilsen, Interaction between four herb compounds and a western drug by CYP3A4 enzyme metabolism in vitro, China Journal of Chinese Materia Medica,2009,34(13):1705-1711
- Cao Chunyu, Hongcai, Wang, Zhao Yong, Liu Ting, Li Chunying, Yi Yan, Wang Jinhua, Xue Baoyun, Timothy M Chan, Odd G Nilsen. Anti-thrombosis effect and its mechanism of Qingkailing injection. China Journal of Chinese Materia Medica,2009,34(12):1549-1552
- Hongcai, Wang, Li Chunying, Liu Ting, Zhao Yong, Cao Chunyu, Xun Baoyun, Wang Jinhua, Study on embryo toxicity of Cinnabaris, China Journal of Chinese Materia Medica,2009,34(21):2794-2798
- Hongcai, Wang. Zebrafish-A Useful Model For Pharmacodynamics And Toxicity Screening Of Traditional Chinese Medicine. China Journal of Chinese Materia Medica,2009,34(22):2839-2842
- Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying . Development of virulent heat-evil-induced thrombosis animal model. China Journal of Chinese Materia Medica,2008,33(18):2124-2128
- Tang Xi-Lan, Hongcai, Wang, Yu Chang-An, Liu Ting, Zhao Yong, Cao Chun-Yu, Li Chun-Ying, Yi Yan, Hao Ran. Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity. China Journal of Chinese Materia Medica,2008,33(17):2164-2169
- Wang Xiukun, Zhao Yong, Hongcai, Wang, Liu Ting, Li Chunying, Tang Xilan, Yi Yan, Tang Hongjun, Ye Zuguang. Experimental study on acute toxicity of climbing groundsel herb from different producing areas. ADRJ, April, 2008,10(2):81-85
- Yi Yan, Hongcai, Wang, Liu Ting, Zhao Yong, Cao Chun-Yu. Analysis of causes for adverse reaction of Yuxingcao injection. China Journal of Chinese Materia Medica,2008,33(21):2439-2439
- Hongcai, W., Timothy M Chan, Analysis and discussion of clinical relativity between virulent heat evils and thrombosis -related diseases, China Journal of Chinese Materia Medica, 2008,33(4):476-481
- Hongcai, W, et al, Inflammatory mechanism for thrombosis and blood stasis animal model induced by endotoxin in combination with carrageenan, China Journal of Chinese Materia Medica, 2007, 32(1):45-48
- Dong Wei, Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying, Wang Xiu-Kun. Cholagogic Effect and Hepatoprotective Effect of Longdan Xiegan Pill (with Caulis Akebial Australis) on Experimental Cholestasis in Mice. China Journal of Chinese Materia Medica,Chinese Journal of Experimental Traditional Medical Formulae, 2007, 13(10):37-40
- Hongcai, Wang, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying. Experimental Study of Gongning Granule on Uterus Haemorrhage Induced by Drug-abortion. Chinese Journal of Experimental Traditional Medical Formulae, 2007, 13(2)::55-57
- Gao Xiao-Xin, Hongcai, Wang, Zhang Su-Qin. Review of Chinese Herbal Medicine of Influencing on Cytochrome p450 System. Chinese Journal of Experimental Traditional Medical Formulae,Chinese Journal of Experimental Traditional Medical Formulae, 2006, 12(9)::64-67
- Hongcai, Wang. Status and Problem of Injection Made from Chinese Medicine. China Journal of Chinese Materia Medica,2007,32(11):1118-1120
Hongcai, Wang,~, Xue Bao-Yun, Wang Jin-Hua, Li Chun-Ying. Inhibition of Qingkailing Injection on Endotoxin-induced Inflammatory Factor Production in Rats. China Journal of Chinese Materia Medica,2007,32(12):1240-1241